Recently, researchers from the St. Jude Hospital discovered the dual effect of an enzyme called TAK1 in the innate immune response. It regulates inflammation and cell death.
TAK1 is known to promote inflammatory responses, and the authors found that the enzyme also inhibits inflammatory responses. The results were published in Journal of Experimental Medicine.
By studying macrophages in mice, the authors demonstrated that TAK1 can limit inflammatory responses and cell death by blocking the activation of NLRP3 inflammasomes. The NLRP3 inflammasome is a type of protein complex that, when activated, recognizes and resists viruses, bacteria, and other threats from the outside world. However, the activation of overactive NLRP3 is accompanied by the occurrence of diseases, including immune disorders.
“Although many studies have demonstrated the role of NLRP3 inflammasomes in the regulation of inflammation, infection, and immune responses, the activation and mechanism of action of NLRP3 have not been clearly revealed,” said the author of the article, Kanneganti: “This new discovery shows that TAK1 is the key to regulate the homeostasis of NLRP3.”
Activation of NLRP3 requires two signals, one of which is the role of TAK1. In the absence of TAK1, macrophages die without NLRP3 activation. However, there is no such effect in the presence of TAK1. However, wild-type macrophages also died after being treated with a TAK1 inhibitor.
The effects of defects in TAK1 include activation of RIPK1 and activation of caspase1. Activation of caspase1 produces both IL-18 and IL-1b cytokines that promote inflammatory cell death (cell death). The researchers also discovered a key factor that mediates this process in the absence of TAK1, including TNFa.
NLRP3 is one of the five major inflammatory bodies involved in innate immune regulation. However, the authors found that NLRP1 was the only inflammatory body that was activated in the absence of TAK1.
This study also showed the role of TAK1 inhibitors for cancer immunotherapy. By inhibiting the activity of TAK1, cell division can be blocked.
Hair loss or baldness isn’t something that’s limited to males only, and females are also affected by this curse. Hair loss is something that not only takes away the hair from a person’s head, but it also takes away his or her confidence and becomes a matter of embarrassment as well.
There are numerous causes behind the problem of hair loss among females and understanding them is the initial step to get an effective solution.
Loss of hair in females has become considerably more obvious nowadays than it was before. A few decades ago, we just used to discover thinning hair in the elderly women. Specialists thought of it as was both expected and acknowledged part of ageing.
As the times have changed, females between the age group of 20 to 50 also start witnessing extreme hair loss, which wasn’t seen before. Young women are afraid to even talk about the possibility of getting bald so early. Shockingly, doctors have started to acknowledge there are many reasons for female baldness. Alopecia, a medical condition that causes hair loss is being diagnosed among many women these days.
Diet And Food
Deficiencies of nutrients in our diet have become far more common these days, and now our food items are filled with harmful sugar, salt, and preservative chemicals. We have almost stopped eating fruits and vegetables, and fill our stomachs with junk food only. This is bad for our hair and overall health as well because iron, protein, Vitamin B is considered important for hair, but these are missing from our diets mostly.
Side effects of medications are seen as another major factor that results in hair loss. Among individuals who suffer from obesity and diabetes, it is quite common to see hair fall problem because the heavy diet consumed by obese people and due to the medicines consumed by diabetics. Women can slow down the speed of their hair fall by improving their diet.
Immune System Disorder
It’s a known fact that diseases are a major reason behind. One sort of baldness occurs because of an immune system problem known as alopecia areata. This type of alopecia can even affect a person’s eyebrows and body hair. The reason for this issue is somewhat hereditary qualities. Apart from deficiencies in our diets and illness, balding can likewise be caused by stress, hormonal imbalance or nutritional deficiency.
Without any question, if you need to discover the causes alone, you can undoubtedly observe, you may need to change your diet or end up losing more hair. It is an unpredictable and complex issue, but there are treatments available to solve baldness problem. Hair transplant treatment in Dubai is one of the most reliable, safe, and highly effective procedure that can bring hair on your head permanently.
As a man, if you’ve heard about the very feminine-focused practice of Orgasmic Meditation you may wonder just what’s in it for you. On the surface, this partnered meditative technique, which is rapidly gaining popularity around the world, could indeed appear to be “all about her”. But more and more men are discovering that practicing the kind of non-goal oriented techniques OM entails provides them with myriad benefits on an emotional, spiritual and physical level.
However, if you think it’s a case of “I’ll have what she’s having”, you may need to adjust your thinking to rewrite your sexual script.
Understanding it’s the Journey Not the Destination
OM involves one partner stroking the other’s clitoris for a 15-minute session, with no goal other than to be entirely present in the experience and deeply feel every sensation it invokes. Because the focus is entirely on the woman’s genitals it might be easy to consider the practice somewhat one sided, but when you accept that it’s not about who’s getting what out of it you’re able to release a host of (often) sub-conscious beliefs around sex that a few seconds of sexual climax is the ultimate goal. And, if you’re seeking enlightenment in the quest of how to attract women, this kind of sexual recalibration can go a long way.
She Feels, He Feels
Women who practice OM report benefits that permeate every area of their lives, including reduction in stress levels, increase in energy and a release of the negative effects of sexual trauma or assault. But here comes the question you really want to ask: “What about me?”
Male OMers claim that the non-goal oriented nature of the practice is highly beneficial for them in ways they had not previously considered. While previously sex was all about focusing on a climax (both their own and, hopefully, their partner’s), enacting this mindful, intimate practice can be extremely confronting, forcing one into an uncomfortable situation that is at the same time humbling and incredibly powerful.
The act of stroking a woman’s clitoris in a repetitive, meditative motion, and being entirely present while doing so with no other goal, cultivates an enhanced level of attention (in, for example, the fingers), which translates to other areas of a man’s life.
Men often report that the removal of the pressure to “perform” opened them up to tuning in to their own body to discover feelings and sensations that they were previously unaware of, or avoided. This ability can be entirely transformational and, in turn, also nurtures a curiosity and willingness to learn within all intimate relationships – not solely the sexual ones. Men OMers report feeling less anxious and more confident in their day-to-day lives, and are also able to engage in more intimate, connected sex.
Women Love Men Who Love Women
While you may think that learning how to attract women invariably comes down to sex, understanding that good sex requires intimacy and vulnerability is vital. By opening yourself up to the “feeling based” language of women, you’ll be able to not just attract them, but also connect with them on a deeper and more meaningful level.
So, if you’re considering exploring ways of how to attract women, Orgasmic Meditation may give you the kind of help you never even knew you needed. Ah, enlightenment…
Dairy is one of nature’s most natural and healthy food products. Think about it, milk is a combination of protein, fat, calcium, and a low-calorie sweetener called lactose. Protein for building strong muscles, calcium for building strong bones, and fat to help with nutrient absorption.
Health Benefits of Wholesome Milk
Source of Nutrition
Milk deficiency can cause severe anaemia, osteoporosis, and other related illnesses. The consumption of milk is essential for maintaining good health and having the energy and strength to do normal activities.
It is the best source of calcium for all age groups, and since calcium is considered the most important mineral for the healthy growth, functioning, repair, and durability of the bones and skeletal system. It will always have a significant role in people’s diets, as a way of preventing calcium deficiency or osteoporosis.
Improves Heart Health
Although most of the focus of calcium is on bones, it has also been shown to reduce cardiovascular diseases and the chances of strokes. Two long-term studies in Japan have positively shown a correlation between daily calcium intake and a reduction in stroke, atherosclerosis, and cardiovascular diseases. Therefore, grab some milk for a healthier heart!
Furthermore, the magnesium and potassium content in it act as vasodilators, which reduces blood pressure, increases blood flow to vital organs, and reduces the stress on the heart and cardiovascular system. The peptides found in it are also believed to inhibit the creation of ACEs, (angiotensin-converting enzymes), which increase blood pressure.
Healthy Bones
As mentioned above, milk is rich in calcium, which is essential for growth and the proper development of a strong bone structure. Bone disorders such as osteoporosis can be prevented with a significant daily intake of milk. Children deprived of cow’s milk have an increased chance of suffering from bone fractures when injured, and their healing time will be significantly higher if they don’t have a steady stream of calcium to aid in the regrowth of bone matter.
Dental Care
Encouraging children and youngsters to drink milk will give them excellent dental health, as it protects the enamel surface against acidic substances. Drinking it for energy and health would also lessen the frequency of children consuming soft drinks, thus reducing the risk of decaying teeth and weak gums.
Acidity Reduction
Consumption of milk products can also help in reducing acidity throughout the body. Drinking cold milk provides relief from acidity.
Wholesome Food
It contains many vitamins and minerals to keep you fit, healthy and strong. A full glass of milk contains vitamins A and B for good eyesight and increasing red blood cell count, carbohydrates for vitality and energy, potassium for proper nerve function and magnesium for muscular function.
It also keeps your body functioning at a youthful level as you get older, more so than some other vitamins and minerals.
So drink wholesome milk on a daily basis. It is absolutely beneficial. One can buy wholesome milk from online grocery shops as they provide you discounts and home delivery offer as well.